| Product Name | PGC-1β Antibody (M-142) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 452-593 mapping within an internal region of PGC-1β of mouse origin |
| Modification Notes | Transcription factors exert their effects by associating with coactivator or corepressor proteins. The coactivator complexes are thought to be constitutively active, requiring only proper positioning in the genome to initiate transcription. Coactivators include the steroid receptor coactivator (SRC) and CREB binding protein (CBP) families that contain histone acetyltransferase (HAT) activity, which modifies chromatin structure. PPAR gamma coactivator-1∫ (PGC-1∫), also known as PERC or PPARGC1B, functions as a transcriptional activator for NRF-1 (nuclear respiratory factor-1), ERå (estrogen receptor alpha) and GR (glucocorticoid receptor). Through its interaction with various receptors, PGC-1∫ is involved in the regulation of mitochondrial biogenesis events such as energy expenditure and non-oxidative glucose metabolism. Expressed throughout the body with the highest expression in brain, heart and skeletal muscle, PGC-1∫ is induced by insulin and repressed by saturated fatty acids. The gene encoding PGC-1∫ is polymorphic and variations in the expressed protein may contribute to the development of obesity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of PGC-1β of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 452-593 mapping within an internal region of PGC-1&beta of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 452-593 mapping within an internal region of PGC-1β of mouse origin |
| Entrez Gene | 133522 |
|---|
| Application Notes | recommended for detection of PGC-1β of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
