| Product Name | MAN2C1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 741-1040 mapping at the C-terminus of MAN2C1 of human origin |
| Modification Notes | Misfolded glycoproteins are deglycosylated by the peptide N-glycanase during the degradation process. Free oligosaccharides released by N-glycanase are catabolized by cytosolic MAN2C1, also designated å-mannosidase 2C1. MAN2C1, a member of the glycosyl hydrolase 38 family, can cleave å 1,2-linked, å 1,3-linked and å 1,6-linked mannose residues and is stimulated by cobalt. The furanose analogs, swainsonine (SW) and 1,4-dideoxy-1,4-imino-d-mannitol (DIM), are known inhibitors of MAN2C1. The inhibition of MAN2C1 can enhance the adhesion of Jurkat T cells, showing a cytoskeletal rearrangement of the cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MAN2C1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 741-1040 mapping at the C-terminus of MAN2C1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 741-1040 mapping at the C-terminus of MAN2C1 of human origin |
| Entrez Gene | 4123 |
|---|
| Application Notes | recommended for detection of MAN2C1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
