Application
Western blot analysis of TAPP2 expression in HeLa whole cell lysate.Application
Western blot analysis of TAPP2 expression in non-transfected: (A) and mouse TAPP2 transfected: (B) 293T whole cell lysates.| Product Name | TAPP2 Antibody (H-60) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 121-180 mapping within an internal region of TAPP2 of human origin |
| Modification Notes | Tandem PH (pleckstrin homology) domain-containing protein 2 (TAPP2) is a widely expressed cytoplasmic adaptor protein related to BAM32. Highest expression levels of TAPP2 are found in heart and kidney tissues. Upon growth factor stimulation and activation of phosphoinositol 3-kinase, TAPP2 is recruited to the plasma membrane and accumulates in F-Actin-rich membrane ruffles. This recruitment occurs through the specific interaction of the TAPP2 C-terminal PH domain with phosphotidylinositol 3,4-bisphosphate. TAPP2 is positively regulated by Fc g RII and SHIP. The overexpression of TAPP2 increases NFAT-dependent transcriptional activation after G cell Ag receptor ligation and increases the sustained phase of the calcium response. TAPP2 may play a role in the activation of B and T cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TAPP2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 121-180 mapping within an internal region of TAPP2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 121-180 mapping within an internal region of TAPP2 of human origin |
| Entrez Gene | 59339 |
|---|
Application
Western blot analysis of TAPP2 expression in HeLa whole cell lysate.
Application
Western blot analysis of TAPP2 expression in non-transfected: (A) and mouse TAPP2 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of TAPP2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
