| Product Name | SIT Antibody (FL-196) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-196 representing full length SIT of human origin |
| Modification Notes | T lymphocytes express several low molecular mass transmembrane adaptor proteins that recruit SH2 domain-containing intracellular molecules to the cell membrane via tyrosine-based signaling pathways. One such protein, SIT (SHP2 interacting transmembrane adaptor protein) is a disulfide-linked homodimeric glycoprotein that is expressed in lymphocytes. SIT is reduced to half its molecular mass via endoglycosidase treatment. It contains five potential tyrosine phosphorylation sites, suggesting a role in TCR-mediated recruitment of SH2 domain-containing intracellular signaling molecules to the plasma membrane. SIT interacts with SHP2 and also with the adaptor protein Grb2. In addition, it is a substrate for the Src protein kinases Fyn, Lck and ZAP-70. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SIT of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-196 representing full length SIT of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-196 representing full length SIT of human origin |
| Entrez Gene | 27240 |
|---|
| Application Notes | recommended for detection of SIT of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
