Application
Western blot analysis of Syne-2 expression in HL-60 whole cell lysate.| Product Name | Syne-2 Antibody (H-109) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 6554-6662 mapping near the C-terminus of Syne-2 of human origin |
| Modification Notes | Synaptic nuclear envelope protein 2 (Syne-2), also referred to as nesprin-2, is a 6,884 amino acid vertebrate protein that interacts with emerin and Lamin A at the nuclear envelope. Syne-2 is highly expressed in kidney, liver, stomach, placenta, spleen, lymphatic nodes and peripheral blood lymphocytes, but can be found in almost all types of cells. Syne-2 contains a C-terminal transmembrane domain (designated the KLS domain) linked by a spectrin-repeat rod domain to an N-terminal paired, Actin-binding, calponin-homology domain. This structure suggests that Syne-2 is capable of mediating signaling between cell membranes and the cytoskeleton. The Syne-2 gene gives rise to many isoforms, which vary largely in size. Mutations in the Syne-2 gene may be linked to a broad range of human diseases, including laminopathies. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Syne-2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 6554-6662 mapping near the C-terminus of Syne-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 6554-6662 mapping near the C-terminus of Syne-2 of human origin |
| Entrez Gene | 23224 |
|---|
Application
Western blot analysis of Syne-2 expression in HL-60 whole cell lysate.| Application Notes | recommended for detection of Syne-2 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
