| Product Name | C1GALT1 Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 1-300 mapping at the N-terminus of C1GALT1 of human origin |
| Modification Notes | C1GALT1 (core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1), also known as T-synthase, is a single-pass type II membrane protein that is involved in various protein modification pathways. Widely expressed and present at high amounts in heart, kidney, liver and placenta, C1GALT1 functions to generate the core of 1 beta-3-galactosyltransferase, an enzyme that transfers galactose from UDP-Gal to Gal-NAc-alpha-1-O-phenyl and is a precursor for many glycoproteins. C1GALT1 binds magnesium as a cofactor and also participates in development of kidney homeostasis, as well as angiogenesis and thrombopoiesis. Defects in the gene encoding C1GALT1 are associated with IgA nephropathy (IgAN), a condition characterized by accumulation of the IgA antibody in the glomerulus, leading to immune-mediated renal disease. Two isoforms of C1GALT1 exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of C1GALT1 of human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of C1GALT1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of C1GALT1 of human origin |
| Entrez Gene | 56913 |
|---|
| Application Notes | recommended for detection of C1GALT1 of human origin by WB, IP, IF and ELISA also reactive with additional species, including canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
