| Product Name | ST8Sia III Antibody (S-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ST8Sia III (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3), also known as SIAT8C, is a 380 amino acid single-pass type II membrane protein that localizes to the membrane of the Golgi apparatus. Expressed in fetal liver and fetal and adult brain, the expression of ST8Sia III is tissue-specific and developmentally regulated. ST8Sia III plays an important role in protein modification and glycosylation, and functions to catalyze the transfer of sialic acid through alpha-2,8-linkage to intact fetuin glycoprotein. ST8Sia III can form polysialic acid (PSA) in vitro directly on alpha-2,3-, alpha-2,6- or alpha-2,8-linked sialic acid. PSA is an important regulator of neuronal plasticity and is present in embryonic brain tissue, where it interacts with NCAM (neural cell adhesion molecule) and plays a crucial role in fetal brain development. The gene encoding ST8Sia III maps to human chromosome 18q21.31. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of ST8Sia III of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with ST8Sia II, ST8Sia IV, and ST8Sia V. also reactive with additional species, including canine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of ST8Sia III of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of ST8Sia III of human origin |
| Entrez Gene | 51046 |
|---|
| Application Notes | recommended for detection of ST8Sia III of mouse, rat and human origin by WB, IF and ELISA non cross-reactive with ST8Sia II, ST8Sia IV, and ST8Sia V. also reactive with additional species, including canine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
