Application
Western blot analysis of α1A-AR expression in PC-3 whole cell lysate.| Product Name | α1A-AR Antibody (H-136) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 331-466 mapping within a C-terminal cytoplasmic domain of α1A-AR of human origin |
| Modification Notes | å1A-adrenergic receptors (å1A-ARs) mediate actions in the sympathetic nervous system through the binding of the catecholamines, epinephrine and norepinephrine. å1A-AR couples to Gq/11 and regulates blood pressure due to changes in vascular tone and cardiac output. Alternative splicing of the ADRA1A gene generates four isoforms with distinct C-termini, and the different expression profile of these subtypes produces distinct patterns of activation. å1A-AR transcripts are abundant in heart, brain, liver and prostate. å1A-AR transcript sizes of 6.0, 4.0, 3.0, and 2.0 kb have been detected in liver. Transcripts of 6.0, 4.0 and 3.0 kb have been detected in heart, and transcripts of 6.0 and 4.0 kb have been detected in prostate. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of α1A-AR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 331-466 mapping within a C-terminal cytoplasmic domain of &alpha 1A-AR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 331-466 mapping within a C-terminal cytoplasmic domain of α1A-AR of human origin |
| Entrez Gene | 148 |
|---|
Application
Western blot analysis of α1A-AR expression in PC-3 whole cell lysate.| Application Notes | recommended for detection of α1A-AR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
