Application
Blots were probed with p-GluR-2/3 (Ser 880/Ser 891): preincubated with cognate phosphorylated peptide (A) and p-GluR-2/3 (Ser 880/Ser 891): (B).| Product Name | p-GluR-2/3 Antibody (Ser 880/Ser 891) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to phosphorylated Ser 880/Ser 891 of GluR-2/3 of human origin |
| Modification | Phosphoralated |
| Modification Notes | Glutamate receptors mediate most excitatory neurotransmission in the brain and play an important role in neural plasticity, neural development and neurodegeneration. Ionotropic glutamate receptors are categorized into NMDA receptors and kainate/AMPA receptors, both of which contain glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors are co-localized with NMDA receptors in many synapses and consist of seven structurally related subunits designated GluR-1 through 7. The kainate/AMPA receptors are primarily responsible for the fast excitatory neurotransmission by glutamate, whereas the NMDA receptors are functionally characterized by a slow kinetic neurotransmission and a high permeability for Ca++ ions. The GluR-2/3 protein is phosphorylated at Ser 880 by protein kinase C (PKC), and this phosphorylation event differentially regulates the binding of several PDZ domain-containing proteins, including PICK1. By blocking interactions between GluR-2/3 and PICK1, the phosphorylation of Glur-2/3 by PKC inhibits the expression of long-term depression of cerebral Purkinje cells in vitro. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIP |
| recommended for detection of Ser 880 phosphorylated GluR-2 of mouse, rat and human origin correspondingly Ser 891 phosphorylated GluR-3 of human origin and correspondingly phosphorylated Ser 885 of mouse and rat origin by WB and IP: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to phosphorylated Ser 880/Ser 891 of GluR-2/3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to phosphorylated Ser 880/Ser 891 of GluR-2/3 of human origin |
| Entrez Gene | 2891 |
|---|
Application
Blots were probed with p-GluR-2/3 (Ser 880/Ser 891): preincubated with cognate phosphorylated peptide (A) and p-GluR-2/3 (Ser 880/Ser 891): (B).| Application Notes | recommended for detection of Ser 880 phosphorylated GluR-2 of mouse, rat and human origin correspondingly Ser 891 phosphorylated GluR-3 of human origin and correspondingly phosphorylated Ser 885 of mouse and rat origin by WB and IP: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
