| Product Name | Y+LAT1 Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 456-510 mapping at the C-terminus of Y+LAT1 of human origin |
| Modification Notes | Y+L amino acid transporter 1 (Y+LAT1), also designated monocyte amino acid permease 2 (MOP-2), is an integral membrane protein. Y+LAT1 is an L-type amino acid transporter (LAT) and belongs to the amino acid-polyamine-organocation (APC) superfamily of proteins. The gene encoding for the Y+LAT1 protein, SLC7A7, which maps to chromosome 14q11.2, has 11 exons and 10 introns spanning 18 kb of genomic DNA. Y+LAT1 shows dibasic amino acid transport activity. Lysinuric protein intolerance (LPI) is an autosomal recessive multisystem disorder caused by defects in the cationic amino acid (CAA) transport at the basolateral membrane of epithelial cells in intestins and kidney. The gene SLC7A7 is mutated in LPI, which is characterized by vomiting, poor feeding, diarrhea and occasionally, episodes of hyperammoniaemic coma. Y+LAT1 is expressed in kidney, lung, peripheral blood leukocytes, placenta, spleen and small intestine. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Y+LAT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 456-510 mapping at the C-terminus of Y+LAT1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 456-510 mapping at the C-terminus of Y+LAT1 of human origin |
| Entrez Gene | 9056 |
|---|
| Application Notes | recommended for detection of Y+LAT1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
