Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of glandular cells.Application
Western blot analysis of TRPC1 expression in rat testis (A) and mouse testis (B) tissue extracts.| Product Name | TRPC1 Antibody (H-105) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 689-793 mapping at the C-terminus of TRPC1 of human origin |
| Modification Notes | Transient receptor potential cation (TRPC) channels are a superfamily of six transmembrane segment-spanning, gated cation channels. TRPC subtypes mediate store-operated Ca2+ entry, a process involving Ca2+ influx and replenishment of Ca2+ stores formerly emptied through the action of inositol 1,4,5-trisphosphate production and other Ca2+ mobilizing agents. TRPC ion channels influence calcium-depletion induced calcium influx processes in response to chemo-, mechano- and osmoregulatory events. Human TRPC1 protein is a 793 amino acid cation channel that is expressed in fetal and adult brain, and adult heart, testis and ovary, where it may influence store-operated Ca2+ entry as a component of capacitative calcium entry (CCE) complexes. The activation of store-mediated Ca2+ entry in human cells occurs through the association between inositol 1,4,5-trisphosphate receptors and TRPC1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of TRPC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 689-793 mapping at the C-terminus of TRPC1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 689-793 mapping at the C-terminus of TRPC1 of human origin |
| Entrez Gene | 7220 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of glandular cells.
Application
Western blot analysis of TRPC1 expression in rat testis (A) and mouse testis (B) tissue extracts.| Application Notes | recommended for detection of TRPC1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
