| Product Name | CKR-3 Antibody (H-52) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 156-207 including an extracellular domain of CKR-3 of human origin |
| Modification Notes | C-C or ∫ chemokine family members are characterized by a pair of adjacent cysteine residues and serve as potent chemoattractants and activators of monocytes and T cells. C-C chemokine receptor family members include CKR-1, CKR-2A, CKR-2B, CKR-3, CKR-4, CKR-5, CKR-6, CKR-7, CKR-8, CKR-9, CKR-10 and the Duffy blood group antigen. Each of these receptors are G protein-coupled, seven pass transmembrane domain proteins whose major physiological role is to function in the chemotaxis of T cells and phagocytic cells to areas of inflammation. However, this receptor family has also been shown to facilitate viral infection. CKR-3 (C-C chemokine receptor type 3), also known as CCR3 or CMKBR3, is a 355 amino acid multi-pass membrane protein that localizes to the cell membrane and belongs to the C-C chemokine receptor family. Expressed in eosinophils, neutrophils and monocytes, CKR-3 functions as a receptor for a variety of proteins, including MCP-3 and MCP-4, thereby influencing intracellular calcium levels and affecting signal transduction throughout the cell. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CKR-3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 156-207 including an extracellular domain of CKR-3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 156-207 including an extracellular domain of CKR-3 of human origin |
| Entrez Gene | 1232 |
|---|
| Application Notes | recommended for detection of CKR-3 of mouse, rat and human origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
