Application
Western blot analysis of TDAG51 expression in Hep G2 whole cell lysate.| Product Name | TDAG51 Antibody (H-150) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Cytotoxic T lymphocyte (CTL)-mediated cytotoxicity constitutes an important component of specific effector mechanisms in immuno-surveillance against virus-infected or -transformed cells. Two mechanisms appear to account for this activity, one of which is the perforin-based process. Independently, a FAS-based mechanism involves the transducing molecule FAS (APO-1) and its ligand (FAS-L). The human FAS (APO-1) protein is a cell surface glycoprotein that belongs to a family of receptors that includes CD40, nerve growth factor receptors and tumor necrosis factor receptors. The FAS antigen is expressed on a broad range of lymphoid cell lines, and is expressed at high levels in T cells subsequent to crosslinking of the T cell receptor (TCR). A previously undescribed protein, TDAG51, restores activation-induced apoptosis in cells that have lost the ability to display Fas in response to activation. Thus, TDAG51 plays a critical role in T cell apoptosis by coupling TCR stimulation to Fas expression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TDAG51 of mouse, rat and human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-150 (deletion 97-131) of TDAG51 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-150 (deletion 97-131) of TDAG51 of human origin |
| Entrez Gene | 22822 |
|---|
Application
Western blot analysis of TDAG51 expression in Hep G2 whole cell lysate.| Application Notes | recommended for detection of TDAG51 of mouse, rat and human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
