| Modification Notes |
The cellular homolog of the v-Mos oncogene, originally derived from the Moloney strain murine sarcoma virus, has now been isolated from several species including human, mouse, chicken and Xenopus. In each of these species, the c-Mos proto-oncogene locus consists of a single exon which encodes Mos, a serine/threonine protein kinase involved in the regulation of the meiotic cell cycle in vertebrate oöcytes. Mos function during oöcyte maturation is thought to be exerted through the stabilization or activation of the maturation promoting factor (MPF) complex. While the level of Mos expression is generally low in somatic cells, Mos is expressed at relatively high levels in germ cells. Mos can efficiently cause oncogenic transformation of somatic cells when ectopically expressed during the G1 phase of the cell cycle. Mos activates MAPK, possibly through direct phosphorylation of the MAPKK MEK-1. |
