Application
Western blot analysis of Integrin α2 expression in A-431 whole cell lysate.Application
Western blot analysis of Integrin α2 expression in MDA-MB-231 (A) and HT-1080 (B) whole cell lysates.Application
Western blot analysis of Integrin α2 expression in PMA-treated human PBL whole cell lysate.Application
Western blot analysis of human recombinant Integrin α2 fusion protein.| Product Name | Integrin α2 Antibody (H-293) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Integrins are heterodimers composed of noncovalently associated transmembrane å and ∫ subunits. The sixteen å and eight ∫ subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counter-receptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. Integrin å2 is responsible for adhesion of platelets and other cells to collagens. Modulation of collagen and collagenase gene expression force generation and organization of newly synthesized extracellular matrix. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Integrin &alpha2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 840-1132 mapping within the extracellular domain of Integrin &alpha 2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 840-1132 mapping within the extracellular domain of Integrin α2 of human origin |
| Entrez Gene | 3673 |
|---|
Application
Western blot analysis of Integrin α2 expression in A-431 whole cell lysate.
Application
Western blot analysis of Integrin α2 expression in MDA-MB-231 (A) and HT-1080 (B) whole cell lysates.
Application
Western blot analysis of Integrin α2 expression in PMA-treated human PBL whole cell lysate.
Application
Western blot analysis of human recombinant Integrin α2 fusion protein.| Application Notes | recommended for detection of Integrin &alpha2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
