| Product Name | NEPH3 Antibody (H-55) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | NEPH3 (nephrin-like protein 3), also referred to as NLG1, FILTRIN or KIRREL2 (kin of IRRE like 2), is a 708 amino acid protein that is a member of the immunoglobulin superfamily of cell adhesion molecules. NEPH3 consists of five extracellular Ig-like repeats, a transmembrane domain, several glycosylation sites and a cytoplasmic domain that has a stretch of nine conserved residues. NEPH3 localizes to the interpodocyte filtration slit in the kidney and to the Langerhans islet beta cells in the pancreas. NEPH3 is thought to be involved in the maintenance of the glomerular filtration barrier in the kidney and in pancreas development. Downregulation of NEPH3 is implicated in several proteinuric diseases. Five isoforms exists due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of NEPH3 of h, m and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 546-600 mapping near the C-terminus of NEPH3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 546-600 mapping near the C-terminus of NEPH3 of human origin |
| Entrez Gene | 84063 |
|---|
| Application Notes | recommended for detection of NEPH3 of h, m and, to a lesser extent, rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
