Application
Western blot analysis of p53CSV expression in non-transfected: (A) and mouse p53CSV transfected: (B) 293T whole cell lysates.| Product Name | p53CSV Antibody (C-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | p53CSV (p53-inducible cell-survival factor), also known as WF-1, HSPC132 or TRIAP1 (TP53 regulated inhibitor of apoptosis 1), is a 76 amino acid protein that localizes to the cytoplasm and perinuclear region of cells. Belonging to the TRIAP1/MDM35 family, p53CSV mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis. p53CSV is induced significantly when cells have a low level of genotoxic stresses, but not when DNA damage is severe. Interaction between p53CSV and HSP 70 may result in modulation of the apoptotic pathway and inhibition of Apaf-1 (apoptosis protease activating factor-1) activity. Regulated by p53, p53CSV plays an important role in p53-mediated cell survival. The gene encoding p53CSV maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of p53CSV of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the C-terminus of p53CSV of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the C-terminus of p53CSV of human origin |
| Entrez Gene | 51499 |
|---|
Application
Western blot analysis of p53CSV expression in non-transfected: (A) and mouse p53CSV transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of p53CSV of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
