| Product Name | VLDLR Antibody (H-95) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2 (1). The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain (2). VLDLR is expressed in brain, heart, skeletal muscle and adipose tissue (1,3). It associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR (4,5). VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase (1,6). This pathway regulates the migration of neurons along the radial glial fiber network during brain development (1,6,7). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of VLDLR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 736-830 of VLDLR of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 736-830 of VLDLR of human origin |
| Entrez Gene | 7436 |
|---|
| Application Notes | recommended for detection of VLDLR of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and bovine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
