| Modification Notes |
RMND1 (required for meiotic nuclear division protein 1 homolog), also known as C6orf96, is a 449 amino acid protein that belongs to the RMD1/sif2 family. Existing as three alternatively spliced isoforms, the gene encoding RMND1 maps to human chromosome 6q25.1 and mouse chromosome 10 A1. Human chromosome 6 contains 170 million base pairs and comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6. |