| Product Name | LIMCH1 Antibody (S-12) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins of the central nervous system that contribute to cell differentiation. LIMCH1 (LIM and calponin homology domains 1), also known as LMO7B and LIMCH1A, is a 1,083 amino acid protein that belongs to the LIMCH1 family. Containing one CH (calponin-homology) domain and one LIM zinc-binding domain, LIMCH1 exists as nine alternatively spliced isoforms. LIMCH1 is encoded by a gene located on human chromosome 4p13. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIFELISA |
| recommended for detection of LIMCH1 isoforms 1-9 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of LIMCH1 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of LIMCH1 of human origin |
| Entrez Gene | 22998 |
|---|
| Application Notes | recommended for detection of LIMCH1 isoforms 1-9 of mouse, rat and human origin by WB, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
