| Product Name | α-2 antiplasmin Antibody (H-275) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 116-390 mapping within an internal region of α-2 antiplasmin of human origin |
| Modification Notes | The serine proteinase inhibitors (serpins) comprise a superfamily of proteins with a diverse set of functions, including the control of blood coagulation, complement activation, programmed cell death and development. Serpins are secreted glycoproteins that contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Alpha-2 antiplasmin (also referred to as Alpha-2-AP or Alpha-2-plasmin inhibitor) is a member of the serpin family that inhibits plasmin. It is the most potent and rapidly acting of the plasmin inhibitors and is thought to play a key role in the regulation of fibrinolysis and degradation of various other proteins. Alpha-2 antiplasmin interferes with the binding of plasminogen to fibrin because lysine residues in its carboxy-terminal region compete with those in fibrin. As plasmin degrades blood clots, impaired activity of Alpha-2 antiplasmin leads to a bleeding tendency. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of α-2 antiplasmin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 116-390 mapping within an internal region of &alpha -2 antiplasmin of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 116-390 mapping within an internal region of α-2 antiplasmin of human origin |
| Entrez Gene | 5345 |
|---|
| Application Notes | recommended for detection of α-2 antiplasmin of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine and bovine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
