| Product Name | ACAD-8 Antibody (H-165) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 251-415 mapping at the C-terminus of ACAD-8 of human origin |
| Modification Notes | ACAD-8 (Acyl-CoA dehydrogenase family member 8), also known as Isobutyryl-CoA dehydrogenase (IBD) or activator-recruited cofactor 42 kDa component (ARC42), consists of an N-terminal å-helical domain, a ∫-sheet domain and another å-helical domain at the C-terminal. The ACAD family of enzymes are involved in the catabolism of fatty acids and amino acids. They provide a major source of energy for the heart and skeletal muscle. ACAD-8 is a mitochondrial flavoprotein involved in valine degradation. It is responsible for converting isobutyryl-CoA to methacrylyl-CoA. ACAD-8 localizes to the mitochondrial matrix and exists as a homotetramer. Deficiency of ACAD-8 results in carnitine deficiency, dilated cardiomyopathy, and formula feeding intolerance. The excretion of isobutyryl-glycine in urine is a sign of an ACAD-8 related defect. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ACAD-8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 251-415 mapping at the C-terminus of ACAD-8 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 251-415 mapping at the C-terminus of ACAD-8 of human origin |
| Entrez Gene | 27034 |
|---|
| Application Notes | recommended for detection of ACAD-8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
