| Product Name | LASS1 Antibody (H-170) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The LASS (longevity assurance homolog) family members are highly conserved from yeasts to mammals. Six members of this family of proteins involved in sphingolipid synthesis have been characterized (LASS1, LASS2, LASS3, LASS4, LASS5 and LASS6). LASS1, also called LAG1, is a 350 amino acid cermide synthase located in the membrane of the endoplasmic reticulum. The gene coding LASS1 is bicistronic, containing both the LASS1 and GDF1 open reading frames. Two isoforms of LASS1 have been characterized. Isoform 2 lacks the last 13 amino acids of the intact protein (isoform 1). The cell death and growth inhibition in head and neck squamous cell carcinoma (HNSCC) brought on by the chemotherapeutic agents gemcitabine and doxorubicin via the activation of caspase-3 and caspase-9 may involve LASS1 overexpression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LASS1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 111-280 mapping within an internal region of LASS1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 111-280 mapping within an internal region of LASS1 of human origin |
| Entrez Gene | 10715 |
|---|
| Application Notes | recommended for detection of LASS1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
