| Modification Notes |
Secretoglobins (Lipophilins, Mammaglobins) are small secreted proteins of endocrine-responsive organs and mucosal epithelia that form multimeric complexes and correlate with the development of various human cancers. Lipophilin A (LIPA, LPHA, secretoglobin, family 1D, member 1; SCGB1D1) and Lipophilin B (LIPB, LPHB, secretoglobin, family 1D, member 2;SCGB1D2) are orthologs of prostatein (estramustine-binding protein), the major secretory glycoprotein of the rat ventral prostate gland. Lipophilin A is a component of a heterodimeric molecule present in human tears. Lipophilin B mRNA can be overexpressed in breast tumors and shows a high degree of correlation with the mRNA expression profile of mammaglobin. Mammaglobin A (MGB1, secretoglobin, family 2A, member 2; SCGB2A2) and Mammaglobin B (MGB2, lipophilin C, LPHC, UGB3, SCGB2A1) histological detection in breast tissue is a reliable diagnostic marker for breast tumors. |