Application
Western blot analysis of L3MBTL2 expression in KNRK nuclear extract.| Product Name | L3MBTL2 Antibody (H-53) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Polycomb group (PcG) proteins are important for maintaining the transcriptionally repressed state of target genes and are thought to function via chromatin modification. L3MBTL2 (Lethal(3)malignant brain tumor-like 2 protein), also known as L3MBT or H-l(3)mbt-l, is a 705 amino acid member of the PcG family. Localized to the nucleus, L3MBTL2 associates with chromatin-remodeling complexes and helps inhibit the expression of proteins that trigger the cell to enter mitosis. During the G0 phase of the cell cycle, L3MBTL2 is part of a complex that contains other proteins (such as HP1©, E2F-6 and Max) that participate in transcriptional repression. L3MBTL2 contains one FCS-type zinc finger and four MBT repeats and is expressed as three isoforms due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of L3MBTL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 141-193 mapping within an internal region of L3MBTL2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 141-193 mapping within an internal region of L3MBTL2 of human origin |
| Entrez Gene | 83746 |
|---|
Application
Western blot analysis of L3MBTL2 expression in KNRK nuclear extract.| Application Notes | recommended for detection of L3MBTL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
