| Product Name | MBNL2 Antibody (H-81) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Pre-mRNA splicing is a critical step in the post-transcriptional regulation of gene expression. Several protein complexes are involved in proper mRNA splicing and transport. The muscleblind proteins, MBNL1, MBNL2 and MBNL3, promote inclusion or exclusion of specific exons on different pre-mRNAs by antagonizing the activity of CUG-BP and ETR-3-like factors bound to distinct intronic sites. MBNL1 and MBNL2, associate with expanded CUG repeats in vitro and localize to the nuclear foci in both DM1 and DM2 (myotonic dystrophy types 1 and 2), suggesting that the nuclear accumulation of mutant RNA is pathogenic in DM1, therefore implicating muscleblind proteins MBNL1 and MBNL2 in the pathogenesis of both disorders. MBNL2, a 367 amino acid protein, participates in recruitment of Intergrin ?3 to focal adhesions in a RNA-dependent protein localization mechanism. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of MBNL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 101-181 mapping within an internal region of MBNL2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 101-181 mapping within an internal region of MBNL2 of human origin |
| Entrez Gene | 10150 |
|---|
| Application Notes | recommended for detection of MBNL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
