| Product Name | Dectin-2 Antibody (M-45) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Together, Dectin-1 and Dectin-2 make up the unique subfamily of dendritic cell-associated C-type lectins. Dectin-2 is expressed on antigen-presenting cells, where it interacts with its putative ligands on T cells. That interaction may deliver co-stimulatory signals in naive T cells. Dectin-2 expression is upregulated during monocyte activation and maturation at inflammatory lesions. Broadband UV-B upregulates Dectin-2 expression in Langerhans cells by activating the Dectin-2 gene promoter, suggesting that this protein plays a crucial role in the mediation of UV-induced immunosuppression. In cattle, Dectin-2 expressed by dendritic cells may also play a role in the recognition of invading antigens in lymph nodes. Dectin-2 functions as a pattern recognition receptor for fungi that activates signaling through FcR© to induce innate immune responses. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Dectin-2 of mouse origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 141-185 mapping within a C-terminal extracellular domain of Dectin-2 of mouse origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 141-185 mapping within a C-terminal extracellular domain of Dectin-2 of mouse origin |
| Application Notes | recommended for detection of Dectin-2 of mouse origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
