| Product Name | neutral ceramidase Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 34-333 mapping within a cytoplasmic domain of neutral ceramidase of human origin |
| Modification Notes | Neutral ceramidase, also known as ASAH2 (N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2), HNAC1, BCDase or NCDase, is a 780 amino acid single-pass type II membrane protein that exists as a precursor which is proteolytically cleaved to produce a soluble active peptide. Expressed ubiquitously with highest levels present in heart, intestine, kidney and skeletal muscle, neutral ceramidase functions to catalyze the hydrolysis of sphingolipid ceramide into sphingosine and free fatty acid, a reaction that occurs at an optimal pH of 6.5-8.5 and is essential for the regulation of sphingolipid signaling metabolites. Additionally, neutral ceramidase plays a role in apoptotic suppression, as well as in the digestion of dietary sphingolipids within intestinal tissue. Multiple isoforms of neutral ceramidase exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of neutral ceramidase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 34-333 mapping within a cytoplasmic domain of neutral ceramidase of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 34-333 mapping within a cytoplasmic domain of neutral ceramidase of human origin |
| Entrez Gene | 56624 |
|---|
| Application Notes | recommended for detection of neutral ceramidase of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
