| Product Name | JMJD2C Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 349-648 mapping within an internal region of JMJD2C of human origin |
| Modification Notes | JMJD2C (jumonji domain containing 2C), also known as GASC1, KDM4C or JHDM3C, is a nuclear protein that belongs to the Jumonji domain 2 (JMJD2) family of histone demethylases. Functioning as a trimethylation-specific demethylase, JMJD2C demethylates specific lysine residues of Histone H3, thereby converting the trimethylated Histone H3 to its dimethylated form and playing a central role in the histone code. Through its ability to modify histones, JMJD2C increases the rate of cell proliferation and promotes the expression of a variety of proteins. JMJD2C binds iron as a cofactor and contains two Tudor domains through which it interacts with methylated histones. Overexpression of JMJD2C is associated with esophageal squamous cell carcinoma, suggesting a possible role for JMJD2C in carcinogenesis. Two isoforms of JMJD2C exist due to alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of JMJD2C of m and h origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 349-648 mapping within an internal region of JMJD2C of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 349-648 mapping within an internal region of JMJD2C of human origin |
| Entrez Gene | 23081 |
|---|
| Application Notes | recommended for detection of JMJD2C of m and h origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
