Application
Western blot analysis of THNSL2 expression in non-transfected: (A) and mouse THNSL2 transfected: (B) 293T whole cell lysates.| Product Name | THNSL2 Antibody (H-90) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Threonine is one of nine essential amino acids that cannot be synthesized by humans and must be supplied in the diet. THNSL2 (threonine synthase-like 2), also known as TSH2, is a 484 amino acid protein belonging to the threonine synthase family. Utilizing pyridoxal phosphate as a cofactor, THNSL2 may function as a catabolic phospholyase on gamma and beta phosphorylated substrates. THNSL2 may also degrade O-phospho-threonine to alpha-ketobutyrate, ammonia and phosphate. Existing as four alternatively spliced isoforms, THNSL2 is encoded by a gene mapping to human chromosome 2p11.2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8 gene defects. An extremely rare recessive genetic disorder, Alström syndrome, is related to mutations in the ALMS1 gene. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of THNSL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 259-348 mapping within an internal region of THNSL2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 259-348 mapping within an internal region of THNSL2 of human origin |
| Entrez Gene | 55258 |
|---|
Application
Western blot analysis of THNSL2 expression in non-transfected: (A) and mouse THNSL2 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of THNSL2 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
