| Modification Notes |
A group of small secreted proteins known as the TAFA family consists of five highly homologous genes: TAFA1, TAFA2, TAFA3, TAFA4 and TAFA5. Members of the TAFA family contain conserved cysteine residues at fixed positions and are highly expressed in brain. The TAFA family may be distantly related to a member of the CC-chemokine family known as MIP-1å, and have been postulated to regulate nervous and immune cells of the brain as neurokines or chemokines. TAFA5 (chemokine-like protein TAFA-5), also known as FAM19A5 (family with sequence similarity 19 (chemokine (C-C motif)-like), member A5), is a 132 amino acid protein that belongs to the FAM19/TAFA family. A single-pass membrane protein, TAFA5 consists of three alternatively spliced variants that are encoded by a gene located on human chromosome 22. TAFA5 isoform 2 is a brain-specific secreted protein |