The organic anion transporter family of proteins mediate hepatic uptake of cardiac glycosides. OATP-F (organic anion transporter F), also known as SLCO1C1 (solute carrier organic anion transporter family member 1C1) or SLC21A14 (solute carrier family 21 member 14), is a 712 amino acid member of the organic anion transporter protein family. As a multi-pass membrane protein, OATP-F mediates the Na+-independent, high affinity transport of the thyroid hormones thyroxine (T4) and rT3 and other organic anions. OATP-F is also thought to transport estrone-3-sulfate and sulfobromophthalein (BSP), triiodothyronine (T3) and 17-beta-glucuronosyl estradiol at a much lower efficiency. OATP-F is expressed highly in Leydig cells in testis and in brain.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of OATP-F of mouse, rat and, to a lesser extent, human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope corresponding to amino acids 1-71 mapping at the N-terminus of OATP-F of mouse origin
Tissue Specificity
epitope corresponding to amino acids 1-71 mapping at the N-terminus of OATP-F of mouse origin