| Product Name | ABCE1 Antibody (H-105) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | ABCE1 (RNS4I, RLI) is a mediator of the 2-5A/RNase L pathway. The 2-5A/ RNase L system is considered an essential pathway of interferon (IFN) action. In the pathway, IFN stimulation activates 2-5A synthetases which convert ATP into a set of atypical oligomers known as 2-5A. These oligomers in turn activate RNase L (RNS4), which leads to inhibition of protein synthesis by cleaving mRNAs at the 3-prime side of UpNp sequences. This inhibition ne-cessitates the association of ABCE1 with RNase L and is dependent on the ratio between the two proteins. The 2-5A/RNase L system could also play a more general physiological role, for instance, in the regulation of RNA stability in mammalian cells. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of ABCE1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-105 mapping at the N-terminus of ABCE1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-105 mapping at the N-terminus of ABCE1 of human origin |
| Entrez Gene | 6059 |
|---|
| Application Notes | recommended for detection of ABCE1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine, porcine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
