Application
Western blot analysis of C1orf51 expression in non-transfected 293T: (A), human C1orf51 transfected 293T: (B), HeLa (C) and COLO 320DM (D) whole cell lysates and HeLa (E) and COLO 320DM (F) nuclear extracts.| Product Name | C1orf51 Antibody (S-20) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf51 gene product has been provisionally designated C1orf51 pending further characterization. There are two isoforms of C1orf51 that are produced as a result of alternative splicing events. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of C1orf51 of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within an internal region of C1orf51 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within an internal region of C1orf51 of human origin |
| Entrez Gene | 148523 |
|---|
Application
Western blot analysis of C1orf51 expression in non-transfected 293T: (A), human C1orf51 transfected 293T: (B), HeLa (C) and COLO 320DM (D) whole cell lysates and HeLa (E) and COLO 320DM (F) nuclear extracts.| Application Notes | recommended for detection of C1orf51 of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
