| Modification Notes |
Tup1 and Ssn6 are yeast proteins that, after being recruited to different promotor regions by DNA-binding proteins, form a transcription repressor complex that regulates gene expression. The Groucho/transducin-like Enhancer of split (TLE) family is the vertebrate ortholog of the Tup family and is functionally paired with the vertabrate Ssn6-like protein UTY. UTY is a product of the ubiquitously transcribed tetratricopeptide-repeat genes found on the Y chromosome. Interacting with TLE1 or TLE2, UTY acts to regulate the expression of particular genes. A related gene, found on the X chromosome, encodes the UTX protein that functions in a similar manner. |