Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing nuclear and membrane localization.Application
Western blot analysis of EXOSC8 expression in non-transfected 293T: (A), mouse EXOSC8 transfected 293T: (B) and HeLa (C) whole cell lysates.| Product Name | EXOSC8 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | The exosome is a multisubunit complex of 3’ to 5’ exoribonucleases. It is involved in a variety of cellular processes and is responsible for degrading unstable mRNAs that contain AU-rich elements in their untranslated 3’ region. EXOSC8 (exosome component 8), also known as p9, CIP3 (CBP-interacting protein 3), EAP2, OIP2 (Opa-interacting protein 2), RRP43 (Ribosomal RNA-processing protein 43) or Rrp43p, is a component of the exosome multienzyme ribonuclease complex. It belongs to the RNase PH family and localizes to the nucleolus. EXOSC8 is one of the six RNase-PH domain subunits of the exosome. Together, these six subunits form a PNPase-like ring. EXOSC8 is required for the processing of the 7S pre-RNA. In addition to its numerous interactions with other proteins, EXOSC8 can also interact with itself. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of EXOSC8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping near the N-terminus of EXOSC8 of human origin |
|---|---|
| Tissue Specificity | epitope mapping near the N-terminus of EXOSC8 of human origin |
| Entrez Gene | 11340 |
|---|
Application
Immunofluorescence staining of formalin-fixed Hep G2 cells showing nuclear and membrane localization.
Application
Western blot analysis of EXOSC8 expression in non-transfected 293T: (A), mouse EXOSC8 transfected 293T: (B) and HeLa (C) whole cell lysates.| Application Notes | recommended for detection of EXOSC8 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
