TBC1D13 (TBC1 domain family member 13) is a 400 amino acid protein that contains one Rab-GAP TBC domain. Existing as two alternatively spliced isoforms, TBC1D13 may act as a GTPase-activating protein for Rab family proteins. The gene that encodes TBC1D13 contains 23,229 bases and maps to human chromosome 9q34.11. Housing over 900 genes, chromosome 9 comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects and Familial dysautonomia, are both associated with chromosome 9. Mutations in DFNB31, located on human chromosome 9, are associated with Usher syndrome type 2, which is characterized by severe rod-cone dystrophy and varying degrees of hearing impairment. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of TBC1D13 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other TBC1D family members also reactive with additional species, including equine, canine, bovine and porcine
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping near the N-terminus of TBC1D13 of human origin
Tissue Specificity
epitope mapping near the N-terminus of TBC1D13 of human origin
Western blot analysis of TBC1D13 expression in non-transfected: (A) and mouse TBC1D13 transfected: (B) 293T whole cell lysates.
Application Notes
recommended for detection of TBC1D13 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other TBC1D family members also reactive with additional species, including equine, canine, bovine and porcine
Additional Information
Form
Liquid
Storage Instructions
For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.