| Product Name | DICE1 Antibody (H-114) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | DICE1 (Deleted in Cancer 1) is a protein mapping to chromosome 13q14, which appears to be a tumor suppressor gene in non-small cell lung carcinoma. Expression of DICE1 is lost or downregulated in most non-small lung carcinomas compared to normal lung tissue. This is most likely due to a loss of heterozygosity (LOH) of chromosome 13, which is prone to deletions and rearrangements in human lung cancers. The DICE1 gene is extremely homologous to the mouse protein, DBI-1, at the carboxy terminus. DBI-1, when expressed at high levels, interferes with the mitogenic response to IGF-1. Both DICE1 and DBI-1 contain the highly conserved DEAD-box motif, which suggests that these proteins are involved in critical aspects of cellular function and regulation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DICE1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 713-826 mapping near the C-terminus of DICE1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 713-826 mapping near the C-terminus of DICE1 of human origin |
| Entrez Gene | 26512 |
|---|
| Application Notes | recommended for detection of DICE1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
