VMAC (vimentin-type intermediate filament associated coiled-coil protein) is a 169 amino acid cytoplasmic protein that colocalizes with vimentin-type intermediate filaments. It is thought that vimentin-type intermediate filaments play an important role in cytoskeletal organization and cell morphology. VMAC consists of a coiled-coil domain in its N-terminal region and a PDZ-binding tetrapeptide consensus motif in its C-terminal region. Abundant in kidney, VMAC is encoded by a gene located on human chromosome 19p13.3. Consisting of around 63 million bases with over 1,400 genes, chromosome 19 makes up over 2% of human genomic DNA. Chromosome 19 includes a diversity of interesting genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin superfamily members including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family, and Fcå receptors.
Key Feature
Clonality
Polyclonal
Isotype
IgG
Host Species
Rabbit
Tested Applications
WBIPIFELISA
recommended for detection of VMAC of human origin by WB, IP, IF and ELISA
Species Reactivity
HumanMouseRat
Concentration
1mg/ml
Purification
Affinity purified
Target Information
Alternative Names
epitope mapping near the C-terminus of VMAC of human origin
Tissue Specificity
epitope mapping near the C-terminus of VMAC of human origin