| Product Name | SPR-5 Antibody (C-95) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 676-770 mapping at the C-terminus of SPR-5 of C. elegans origin |
| Modification Notes | Presenilins are components of a protease complex that functions to cleave Notch receptors and the Amyloid precursor protein implicated in Alzheimer’s disease. Mutations in Presenilin 1 and Presenilin 2 are the most common cause of familial early-onset Alzheimer’s disease. A mutation in the Sel-12 presenilin protein is associated with a highly penetrant egg-laying defect caused by a reduction in Notch signaling. The transgenic expression of HOP-1 can rescue a SEL-12 mutant from the egg-laying defect. SPR-5 (suppressor of presenilin defect family member 5) is a 770 amino acid protein that, when mutated, efficiently suppresses the egg-laying defect of the SEL-12 mutant by releasing the repression of HOP-1 expression during developmental stages. SPR-5 is similar to the mammalian PAO protein and is believed to associate with SPR-1, a C. elegans homolog of CoREST-like co-repressor complex that functions in transcriptional repression. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of SPR-5 of ce origin by WB, IP, IF and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 676-770 mapping at the C-terminus of SPR-5 of C. elegans origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 676-770 mapping at the C-terminus of SPR-5 of C. elegans origin |
| Application Notes | recommended for detection of SPR-5 of ce origin by WB, IP, IF and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
