Application
Western blot analysis of TAB3 expression in c4 whole cell lysate.| Product Name | TAB3 Antibody (H-128) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 49-176 mapping near the N-terminus of TAB3 of human origin |
| Modification Notes | TAB1, TAB2 and TAB3 (for TAK1 binding proteins) interact with the MAPKKK TAK1 in response to various stimuli. TAB1 activates TAK1 in TGF-∫ mediated signaling. In response to proinflammatory signals, TAB2 complexes with TRAF6 and TAK1, leading to translocation of the complex from the membrane to the cytosol and the subsequent activation of TAK1. When overexpressed, TAB3 activates both NF-kB and AP-1 transcription factors. In response to TNF-å or IL-1, TAK1 complexes with TAB1 and TAB2 or with TAB1 and TAB3 to yield two distinct complexes. Both TAB2 and TAB3 are important mediators of TAK1 activation in IL-1 and TNF signal transduction. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of TAB3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and avian: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 49-176 mapping near the N-terminus of TAB3 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 49-176 mapping near the N-terminus of TAB3 of human origin |
| Entrez Gene | 257397 |
|---|
Application
Western blot analysis of TAB3 expression in c4 whole cell lysate.| Application Notes | recommended for detection of TAB3 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine and avian: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
