| Product Name | CENPJ Antibody (H-300) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | CENPJ (CPAP) is a centromeric protein that plays a role in brain size. The protein contains five coiled-coil domains, the most C-terminal of which includes a leucine zipper motif. CENPJ also has several potential protein phosphoryl-ation sites and a C-terminal domain containing 21 nonamer G-box repeats. The CENPJ gene is expressed in neuroepithelium during prenatal neurogenesis, and it localizes to the spindle poles of cells undergoing mitosis. This localization suggests that a centrosomal mechanism controls neuron number in the developing mammalian brain. Mutations in the CENPJ gene have been linked to the condition autosomal recessive primary microcephaly. A novel 4 bp deletion in the gene has been characterized as a cause of protein truncation leading to the condition. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of CENPJ of human origin by WB, IP, IF and ELISA | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 1-300 mapping at the N-terminus of CENPJ of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 1-300 mapping at the N-terminus of CENPJ of human origin |
| Entrez Gene | 55835 |
|---|
| Application Notes | recommended for detection of CENPJ of human origin by WB, IP, IF and ELISA |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
