Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human seminal vesicle tissue showing cytoplasmic staining of glandular cells.| Product Name | TICAM-2 Antibody (H-85) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | TICAM-1, also known as Toll-interleukin 1 receptor domain (TIR)-containing adaptor molecule, maps at chromosome 19p13.3. It can physically bind the TIR domain of Toll-like receptor 3 (TLR3) and activate the IFN-beta promoter. TLR proteins are signaling molecules that can recognize pathogen associated molecular patterns and may function as a link between the innate and adaptive immune responses. TICAM-1 mediates dsRNA-TLR3-dependent production of IFN-beta. This TICAM-1-dependent pathway is important for other TLR-IFN-beta pathways, which form part of the MyD88-independent cellular immune response. TICAM-2, a cytoplasmic protein, physically bridges TLR4 and TICAM-1 and functionally transmits LPS-TLR4 signaling to TICAM-1, which in turn activates IRF-3. In its structural features, TICAM-2 resembles Mal/TIRAP, an adapter that links TLR2/4 and MyD88. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFIHCELISA |
| recommended for detection of TICAM-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 142-226 mapping near the C-terminus of TICAM-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 142-226 mapping near the C-terminus of TICAM-2 of human origin |
| Entrez Gene | 353376 |
|---|
Application
Immunoperoxidase staining of formalin fixed, paraffin-embedded human seminal vesicle tissue showing cytoplasmic staining of glandular cells.| Application Notes | recommended for detection of TICAM-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA also reactive with additional species, including equine, canine, bovine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
