| Product Name | atrophin-2 Antibody (H-113) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | Atrophin-2 (Arginine-glutamic acid dipeptide repeats protein, Atrophin-1-like protein) is a 1,566 amino acid protein encoded by the human gene RERE. Atrophin-2 is a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins and contains one BAH domain, one ELM2 domain, one GATA-type zinc finger and one SANT domain. Atrophin-2 plays a role as a transcriptional repressor during development and later may play a role in cell survival. Overexpression of atrophin-2 recruits Bax to the nucleus, particularly to the promyelocytic leukemia (PML) nuclear body, also known as the PML oncogenic domain (POD), and triggers caspase-3 activation, leading to cell death. Atrophin-2 also interacts with HDAC1 and atrophin-1. Its interaction with atrophin-1 is improved when the poly-Gln region of atrophin-1 is extended. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Atrophin-2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with atrophin-1 also reactive with additional species, including equine, canine, bovine and avian | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 587-699 mapping within an internal region of Atrophin-2 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 587-699 mapping within an internal region of Atrophin-2 of human origin |
| Entrez Gene | 473 |
|---|
| Application Notes | recommended for detection of Atrophin-2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with atrophin-1 also reactive with additional species, including equine, canine, bovine and avian |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
