Application
Western blot analysis of FRMD8 expression in non-transfected: (A) and mouse FRMD8 transfected: (B) 293T whole cell lysates.| Product Name | FRMD8 Antibody (N-16) |
|---|---|
| Antibody Type | Primary Antibodies |
| Modification Notes | FERM domains are roughly 150 amino acids in length and are found in a number of cytoskeletal-associated proteins such as Ezrin, Radixin, Moesin and 4.1 (erythrocyte membrane protein band 4.1), where they provide a link between cytoskeletal signals and membrane dynamics. FRMD8 (FERM domain-containing protein 8), also known as FKSG44, is a 464 amino acid protein containing one FERM domain. Existing as two alternatively spliced isoforms, the gene encoding FRMD8 maps to human chromosome 11q13.1. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of FRMD8 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other FRMD family members also reactive with additional species, including canine and porcine | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping at the N-terminus of FRMD8 of human origin |
|---|---|
| Tissue Specificity | epitope mapping at the N-terminus of FRMD8 of human origin |
| Entrez Gene | 83786 |
|---|
Application
Western blot analysis of FRMD8 expression in non-transfected: (A) and mouse FRMD8 transfected: (B) 293T whole cell lysates.| Application Notes | recommended for detection of FRMD8 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with other FRMD family members also reactive with additional species, including canine and porcine |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
