Application
Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.Application
Western blot analysis of DGCR2 expression in non-transfected 293T: (A), human DGCR2 transfected 293T: (B) and HeLa (C) whole cell lysates.| Product Name | DGCR2 Antibody (C-14) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope mapping within a C-terminal cytoplasmic domain of DGCR2 of human origin |
| Modification Notes | DGCR2 (DiGeorge syndrome critical region gene 2), also known as IDD (integral membrane protein, deleted in DGS) is a 550 amino acid single-pass membrane protein that primarily functions as an adhesion receptor and is thought to be involved in cell-matrix or cell-cell interactions, therefore playing an important role in cell migration and differentiation. Due to the chromosomal location of the gene encoding DGCR2, it is suspected that a defect in this gene is involved in the pathogenesis of Digeorge syndrome, also known as velocardiofacial syndrome, which is a complex syndrome involving multiple organs with symptoms such as cardiac defects, cleft palate and a characteristic facial appearance. The chromosomal region of 22q11.21 is also frequently found deleted in schizophrenic patients, suggesting that downregulation of DGCR2 may be implicated in the disease. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of DGCR2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with DGCR 6 and DGCR 14: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope mapping within a C-terminal cytoplasmic domain of DGCR2 of human origin |
|---|---|
| Tissue Specificity | epitope mapping within a C-terminal cytoplasmic domain of DGCR2 of human origin |
| Entrez Gene | 9993 |
|---|
Application
Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.
Application
Western blot analysis of DGCR2 expression in non-transfected 293T: (A), human DGCR2 transfected 293T: (B) and HeLa (C) whole cell lysates.| Application Notes | recommended for detection of DGCR2 of mouse, rat and human origin by WB, IP, IF and ELISA non cross-reactive with DGCR 6 and DGCR 14: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
