Application
Western blot analysis of TBRG1 expression in mouse kidney tissue extract.| Product Name | TBRG1 Antibody (N-22) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | recommended for detection of TBRG1 of mouse and human origin by WB and ELISA |
| Modification Notes | TBRG1 (transforming growth factor beta regulator 1), also known as TB-5 or NIAM, is a 411 amino acid protein that localizes to the nucleus and contains one FY-rich C-terminal domain and one FY-rich N-terminal domain. Expressed in a variety of tissues, including liver, lung and pancreas, TBRG1 functions as a growth inhibitor that interacts with p14 ARF and MDM2 and is involved in maintaining chromosome stability. Additionally, TBRG1 can activate p53 function, thereby causing cell-cycle arrest and effectively restricting cell proliferation. TBRG1 expression is downregulated in breast, pancreas and kidney tumors, suggesting that TBRG1 participates in tumor suppression. TBRG1 exists as multiple alternatively spliced isoforms and is subject to MDM2-mediated ubiquitination and subsequent proteasomal degradation. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBELISA |
| WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | recommended for detection of TBRG1 of mouse and human origin by WB and ELISA |
|---|---|
| Tissue Specificity | recommended for detection of TBRG1 of mouse and human origin by WB and ELISA |
| Entrez Gene | 84897 |
|---|
Application
Western blot analysis of TBRG1 expression in mouse kidney tissue extract.| Application Notes | WB:1:500~1:2000 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
