Application
Western blot analysis of Retinal RX2 expression in Jurkat whole cell lysate.| Product Name | Retinal RX2 Antibody (A-17) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | raised against Retinal RX2 of human origin |
| Modification Notes | Retinal RX2, also known as RAX2, QRX, RAXL1, ARMD6 or CORD11, is a 184 amino acid nuclear protein that contains one homeobox DNA-binding domain. Localized to the nucleus and preferentially expressed in the inner and outer nuclear layers of the retina, Retinal RX2 is thought to play a role in eye development, possibly modulating the expression of photoreceptor-specific genes. Via its homeobox domain, Retinal RX2 transactivates elements of the rhodopsin promotor, thereby modulating rhodopsin expression within the eye. Defects in the gene encoding Retinal RX2 are the cause of age-related macular degeneration type 6 (ARMD6) and cone-rod dystrophy type 11 (CORD11). While both ARMD6 and CORD11 result in impaired vision, ARMD6 is associated with accumulated protein and fat beneath the retinal pigment epithilium and CORD11 is associated with rod and cone photoreceptor degeneration. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPELISA |
| recommended for detection of Retinal RX2 of human origin by WB, IP and ELISA: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | raised against Retinal RX2 of human origin |
|---|---|
| Tissue Specificity | raised against Retinal RX2 of human origin |
| Entrez Gene | 84839 |
|---|
Application
Western blot analysis of Retinal RX2 expression in Jurkat whole cell lysate.| Application Notes | recommended for detection of Retinal RX2 of human origin by WB, IP and ELISA: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
