| Product Name | LRIG1 Antibody (H-108) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 103-210 mapping within an N-terminal extracellular domain of LRIG1 of human origin |
| Modification Notes | Leucine-rich repeats and immunoglobulin-like domains protein 1, also designated LIG1 or LRIG1, interacts with the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. LRIG1 is a single-pass, type I membrane protein with an ectodomain containing 15 leucine-rich repeats which is sometimes cleaved into N-terminal and C-terminal fragments. LRIG1 is produced in all human glioma cell lines and localizes to perinuclear compartments, cytoplasmic compartments and the cell surface. It acts as a negative feedback regulator of signaling through enhanced receptor ubiquitination and accelerated intracellular degradation. LRIG1 may function as a tumour suppressor since it downregulates the expression of EGF and the related proteins ErbB-2, ErbB-3 and ErbB-4, which all inhibit cancer cells from growth, migration and invasion. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of LRIG1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 103-210 mapping within an N-terminal extracellular domain of LRIG1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 103-210 mapping within an N-terminal extracellular domain of LRIG1 of human origin |
| Application Notes | recommended for detection of LRIG1 of mouse, rat and human origin by WB, IP, IF and ELISA also reactive with additional species, including equine, canine, bovine and porcine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
