| Product Name | Hugl-1 Antibody (H-126) |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | epitope corresponding to amino acids 937-1062 mapping at the C-terminus of Hugl-1 of human origin |
| Modification Notes | Hugl-1 is a cortical cytoskeleton protein involved in the regulation of mitotic spindle orientation, differentiation, proliferation and tissue organization of neuroepithelial cells. It localizes to the cytoplasm and is found in a complex involved in maintaining cell polarity and epithelial integrity. Hugl-1 is associated with nonmuscle Myosin II heavy chain and interacts with PRKCI/aPKC, PARD6B/Par-6, PARD6A and STX4A. The Hugl-1 protein is expressed in kidney, brain and muscle. Expression of Hugl-1 increases cell adhesion and decreases cell migration. Hugl-1 functions as a tumor suppressor in humans, and loss of Hugl-1 expression contributes to colorectal caner and melanoma progression. LLGL1, the gene encoding for Hugl-1, has significant homology to the Drosophila tumor suppressor gene, l(2)gl, which encodes the protein Lgl. Like Hugl-1, Lgl is also a cortical cytoskeleton protein involved in maintaining cell polarity and epithelial integrity. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WBIPIFELISA |
| recommended for detection of Hugl-1 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Alternative Names | epitope corresponding to amino acids 937-1062 mapping at the C-terminus of Hugl-1 of human origin |
|---|---|
| Tissue Specificity | epitope corresponding to amino acids 937-1062 mapping at the C-terminus of Hugl-1 of human origin |
| Entrez Gene | 3996 |
|---|
| Application Notes | recommended for detection of Hugl-1 of human and, to a lesser extent, mouse and rat origin by WB, IP, IF and ELISA also reactive with additional species, including canine: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | For short-term storage, store at 4° C. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles. |
| Storage Buffer | phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
